Antidepressant-like effects of piperine and its neuroprotective mechanism / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1562-1565, 2009.
Article
en Zh
| WPRIM
| ID: wpr-344580
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the antidepressant effect of piperine and its neuroprotective mechanism.</p><p><b>METHOD</b>The behavioral studies were performed in forced swimming test (FST) and tail suspension test (TST). To further explore the mechanisms underlying their antidepressant-like activities, CORT-induced neuroblastoma SH-SY5Y cells and isolated and cultured neural progenitor cells. By using MTT assay, the effect of piperine on neural cells proliferation was observed.</p><p><b>RESULT</b>The research results indicated that after a week of administration, piperine (10, 20 mg x kg(-1)) could significantly reduce the duration of immobility in both FST and TST. Piperine has the protective effect on neuroblastoma cells and increased proliferation of hippocampus neural progenitor cells.</p><p><b>CONCLUSION</b>In the present study, we demonstrated that the antidepressant-like effects of piperine and its mechanisms might be involved by up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity.</p>
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Índice:
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Asunto principal:
Piperidinas
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Células Madre
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Distribución Aleatoria
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Línea Celular
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Células Cultivadas
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Fármacos Neuroprotectores
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Biología Celular
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Proliferación Celular
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Alcaloides
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Benzodioxoles
Límite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Article