Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 610-615, 2012.
Article
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| WPRIM
| ID: wpr-347147
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats.</p><p><b>METHODS</b>Fifty male Sprague-Dawley rats were randomized into a sham-operation group (sham group, n=10), normal saline group (NS group, n=20), and TMP group (n=20). The rats in the NS and TMP groups underwent cecal ligation and puncture (CLP) to induce sepsis. Rats in the NS group were injected with NS (10 mL/kg) immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP (10 mg/kg) at the same time points. Twenty-four hours after modeling, the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α (TNF-α) were also tested. The correlation between TNF-α and the ejection fraction (EF) was observed. Left ventricle specimens were reserved for histomorphologic study.</p><p><b>RESULTS</b>Compared with the sham group, the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels (P <0.05). The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group (P <0.05). Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value (r=-0.583,P=0.000).</p><p><b>CONCLUSION</b>TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function.</p>
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Índice:
WPRIM
Asunto principal:
Patología
/
Farmacología
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Pirazinas
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Volumen Sistólico
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Sangre
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Diagnóstico por Imagen
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Análisis de Supervivencia
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Ultrasonografía
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Factor de Necrosis Tumoral alfa
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Ratas Sprague-Dawley
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Chinese journal of integrative medicine
Año:
2012
Tipo del documento:
Article