BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 345-349, 2007.
Article
en Zh
| WPRIM
| ID: wpr-357701
Biblioteca responsable:
WPRO
ABSTRACT
Adenovirus carrying BMP-2 gene, after being mixed with fibrinous gel, was siphoned off on biodegradable scaffolds (PLA/PCL). The composite was used to repair 1.5 cm long radius defect in rabbits. Four methods were in use in the experiments: Ad-BMP-2 plus fibrinous gel and PLA/PCL (Group A), reconstructed hBMP-2 plus fibrinous gel and PLA/PCL (Group B), Ad-Lacz plus fibrinous gel and PLA/PCL (Group C), and fibrinous gel and PLA/PCL (Group D). Results showed that the defects treated in Group A were repaired with much more new bone regenerated, bridged earlier and stronger than those in Group B 12 weeks after operation. The defects treated in the other two groups could not attain osseous tissue healing. BMP-2 gene carried by biodegradable scaffold and fibrinous gel is easy to conduct and has very strong osteoinduction ability. It is really a good method to repair segmental bone defects.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Poliésteres
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Polímeros
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Fracturas del Radio
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Terapéutica
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Materiales Biocompatibles
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Caprolactama
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Terapia Genética
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Adenoviridae
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Química
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Curación de Fractura
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Año:
2007
Tipo del documento:
Article