Separation of Ephedrine Isomers with Non-aqueous Capillary Electrophoresis / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 213-216, 2001.
Article
en Zh
| WPRIM
| ID: wpr-433954
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WPRO
ABSTRACT
AIM Here the development of a simple, rapid and simultaneous method for the separation of five ephedrine alkaloids obtained with non-aqueous capillary electrophoresis (NACE) were reported. The effects of the electrolyte, non-aqueous solvent on the separation were also discussed. METHODS A running buffer of 50 mmol/L ammonium acetate in methanol was found to be the most suitable for this separation. RESULT The best separation was achieved within 8 minutes. CONCLUSION The separation is not only dependent on differences in the pK value of the alkaloids but also on the intramolecular interaction and solvation. So much improved selectivity could be achieved in nonaqueous medium.
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WPRIM
Idioma:
Zh
Revista:
Journal of China Pharmaceutical University
Año:
2001
Tipo del documento:
Article