Influence of PIMT on apoptosis of fibroblast-like synoviocytes in rheumatoid ar-thritis / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 1015-1018, 2014.
Article
en Zh
| WPRIM
| ID: wpr-454797
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WPRO
ABSTRACT
To prove the influence of protein isoaspartyl-methyltransferase ( PIMT ) on the cell apoptosis of fibroblast-like synoviocytes of RA.Methods: The expression vector of PIMT was constructed and transfected in to the RA-FLS, the impact of PIMT on the cell apoptosis of RA-FLS was observed by overexpressing the vector of PIMT.Results:The mRNA and protein level of PIMT in RA-FLS was increased after transfected the vector of PIMT into RA-FLS;compared with the normal cultured RA-FLS and the RA-FLS transfected with the empty vectors ,the cell apoptosis level was also increased.Conclusion:The decreased expression level of PIMT in RA-FLS is an important reason for reduce apoptosis of RA-FLS,and PIMT can affect the imbalance of proliferation/ap-optosis in the RA-FLS.
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WPRIM
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Zh
Revista:
Chinese Journal of Immunology
Año:
2014
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Article