Effects of Guhong Injection on Expression of Vascular Endothelial Growth Factor in Cortex after Cerebral Isch-emia-reperfusion in Rats / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
; (12): 770-772, 2015.
Article
en Zh
| WPRIM
| ID: wpr-461352
Biblioteca responsable:
WPRO
ABSTRACT
Objective To study the effects of Guhong injection on the expression of vascular endothelial growth factor (VEGF) in the cortex 14 days after cerebral ischemia-reperfusion. Methods 30 male Sprague-Dawley rats were divided into sham group (n=6), ischemia group (n=6), aceglutamide injection group (n=6), Honghua injection group (n=6) and Guhong injection group (n=6). The middle cerebral ar-teries of all the rats were occluded for 2 hours and reperfusion, except the sham group. Drugs were administered once a day 24 hours after re-perfusion. The expression of VEGF in cortex was detected with enzyme-linked immunosorbent assay (ELISA) 14 days after reperfusion. Re-sults The expression of VEGF decreased in the ischemia group compared with the sham group (P<0.001), and it increased both in the ace-glutamide and Guhong injection groups compared with the ischemia group (P<0.05). Conclusion Guhong injection can significantly in-crease the expression of VEGF in the cortex 14 days after ischemia-reperfusion, which may be one of the ways for neuro-protection.
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Rehabilitation Theory and Practice
Año:
2015
Tipo del documento:
Article