EFFECT OF INTRACEREBRAL VENTRICULAR ADMINISTRATION OF ADRENOMEDULLIN ON BLOOD GLUCOSE AND ITS REGULATORY HORMONES IN RATS / 中华内分泌代谢杂志

ABSTRACT

After intracerebral ventricular administration of adrenomedullin (AM) in normal saline (NS) or 30% glucose to rats, the effects on blood glucose and glucose regulatory hormones were studied and compared. 1) Am in NS increased significantly the concentration of plasma insulin and C peptide, and decreased the concentration of glucagon and blood glucose. 2) As compared with 30% glucose alone, AM in 30% glucose raised significantly the plasma insulin and C peptide and decreased significantly the glucagon concentration, but the blood glucose level remained unchanged. The results showed that the AM plays a role in the regulation of pancreatic hormone secretion by central nerve system.