Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to lung cancer / 中国癌症杂志
China Oncology
; (12)1998.
Article
en Zh
| WPRIM
| ID: wpr-541691
Biblioteca responsable:
WPRO
ABSTRACT
Purpose:The current study analyzed the polymorp hisms of DNA repair gene XRCC1 and relationship between genetic variations and s usceptibility to lung cancer Methods:A case-control study of 111 patients with lung cancer a nd 210 normal residents as controls was conducted to detect XRCC1 polymorphisms at Arg399Gln loci . Genotypes were analyzed by PCR-based restriction fragment le ngth polymorphism(RLFP) techniques. Results:XRCC1 codon 399 heterozygous genotype Arg/Gln might hav e weaker protection effect on squamous cell carcinoma and reduce the risk of lun g cancer on smokers. Homozygous genotype Gln/Gln of XRCC1 codon 399 might increa se the risk of lung cancer and have synergistic effect with smoking. Conclusions:The results demonstrated that genetic polymorphism of XRCC1 DNA repair gene might contribute to the susceptibility to lung cancer a nd have synergistic effect with smoking.
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
China Oncology
Año:
1998
Tipo del documento:
Article