Increased production of hepatic platelet activating factor (PAF) and PAF receptors in CCl_4 -induced liver cirrhosis: its implications in chronic liver injury / 解放军医学杂志
Article
en Zh
| WPRIM
| ID: wpr-555782
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the role of platelet activating factor(PAF) and its receptor in portal hypertension in liver cirrhosis. Methods A model of hepatic cirrhosis was replicated in rat by intraperitoneal injection of CCL 4 for 8 weeks. The blood and hepatic PAF and PAF receptors contents were assayed with ELISA, RT-PCR and saturation binding technique. Results Compared with control rats, cirrhotic rats had higher hepatic PAF levels, hepatic PAF output, and plasma PAF levels, which were increased by 44%, 87.7% and 54.5%(P
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Medical Journal of Chinese People's Liberation Army
Año:
2001
Tipo del documento:
Article