Effect of melatonin on GAD67 mRNA expression in post-SE rat hippocampus induced by pilocarpine / 第三军医大学学报
Journal of Third Military Medical University
; (24)2003.
Article
en Zh
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| ID: wpr-562058
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ABSTRACT
Objective To probe the mechanism of anticonvulsant by melatonin from the angle of neurotransmitter.Methods Rat status epilepticus(SE) model was induced by pilocarpine(PILO).?-aminobutyric acid(GABA) content and glutamin acid decarboxylase(GAD)67 mRNA expression was detected at 6,48,72 h,and 7 d in the hippocampus of post-SE rats.The effect of melatonin on these changes was observed.Results GABA content was significantly lower in the hippocampus than in control(P
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Zh
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Journal of Third Military Medical University
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2003
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Article