Application of periosteal cells in bone tissue engineering / 中国组织工程研究

ABSTRACT

As the development of orthopaedics and tranmstology, treatment of bone defect is a major puzzle, and is so apparent that we need a more effective therapeusis urgently. The periosteum contains a lot of osteogenitor cells, which can self-duplicate and multi-directional differentiation. When the tissue is damaged, these cells will participate in tissue repair. In vitro cultured periosteal cells and periosteal cells injected into the small coloboma of bone have been succeeded. On the adequate biodegradable scaffolds, being regulated by some cell factors, periosteal cells can generate bone tissue that are at equal pace in tissue morphology and chemical composition of natural bone. The new bone can be juncture with vivo-bone and continue growing. It is of importance to seek a suitable scaffold materials and in vitro induction condition and to make bone formation in vitro from periosteal cells in bone tissue engineering research for clinical application.