Research Progress in β-Glucuronidase / 中国药师
China Pharmacist
; (12): 1834-1838, 2017.
Article
en Zh
| WPRIM
| ID: wpr-660873
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To summarize the structure, properties and biological functions ofβ-glucuronidase. Methods:By referring to the relevant literatures at home and abroad onβ-glucuronidase in recent years, this paper induced, analyzed and drew conclusions. Results:The crystal structure of humanβ-glucuronidase is comprised of three distinct structural domains. The most common mutation of β-glucuronidase is missense mutation, which results in the change of enzyme activity, and then induces a series of pathological chan-ges like MPSⅦ. The researches on β-glucuronidase used in antibody-directed enzyme prodrug drug therapy and enzyme replacement therapy are becoming deeper and deeper. Conclusion:β-Glucuronidase as an important acid hydrolytic enzyme in human has a variety of genetic mutations, and plays an important role in the fields of medicine and disease diagnosis, which has become one of research hotspots.
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WPRIM
Idioma:
Zh
Revista:
China Pharmacist
Año:
2017
Tipo del documento:
Article