THE MECHANISM OF DILATING VASCULAR SMOOTH MUSCLE BY N-METHYLBERBAMINE / 中国药理学通报

ABSTRACT

The study showed that NMBA could inhibit the rabbit thoracic aorta contractions induced by KC1, CaCl2 and NA, and the pD' 2 values were 3.44, 3.67 and 3.73 respectively. NMBA could also antagonize the extracellular Ca2 + contraction of NA with no effect on the intra-cellular Ca2+ contraction. Comparing with verapamil, the mechanism of NMBA action was inferred to blocking Ca2+ influx during excitation. However, further study will be needed.