Effect of Rosiglitazone on Serum MMP-9 Concentration and Expression of Peripheral Monocyte MMP-9 mRNA in Rats with Diabetes / 药物流行病学杂志
Chinese Journal of Pharmacoepidemiology
; (4)2007.
Article
en Zh
| WPRIM
| ID: wpr-683561
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WPRO
ABSTRACT
Objective:To observe the effect of rosiglitazone on serum MMP-9 con-centration and expression of peripheral monocyte MMP-9 in rats with diabetes.Method:Thirty SD rats were randomly divided into 3 groups:control group(n=10),diabetes group(n=10)and rosiglitazone group(n=10).The rat diabetic model was made by the intra- peritoneal injection of streptozocin.After the model was made successfully,the rats of rosightazone group were treated with rosiglitazone(5 mg?kg~(-1)?d~(-1)for 28d)by garage and the rats of control group and diabetes group were treated with normal saline.The concentration of serum MMP-9 were detected by Enzyme-linked Immunosorbent Assay(ELISA).The expres- sion of peripheral monocyte MMP-9 mRNA were measured by RT-PCR.Result:The concentration of serum MMP-9 were lowered by rosiglitazone treatment.The expression of peripheral monocyte MMP-9 mRNA were inhibited by rosightazone treatment too.Conclusion:Rosiglitazone may be stable artery atherosclerosis plaque through inhibit the mRNA expression of MMP-9.
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WPRIM
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Zh
Revista:
Chinese Journal of Pharmacoepidemiology
Año:
2007
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Article