NLRC3 Attenuates Colon Cancer by Down-Regulating PI3K-mTOR Signaling
Journal of Bacteriology and Virology
; : 67-71, 2018.
Article
en En
| WPRIM
| ID: wpr-715375
Biblioteca responsable:
WPRO
ABSTRACT
The nucleotide-binding oligomerization domain-like receptors (NOD-like receptors, NLRs) are intracellular sensors. Most of them positively affect inflammatory responses, particularly the inflammasome forming NLRs. On the other hand, several studies on gene-deficient mice have revealed that several NLRs negatively influence innate immune responses. Some recent studies have identified a novel sub-group of non-inflammasome forming NLRs that negatively influence different pathways related to inflammation and carcinogenesis. Cytosolic pattern recognition receptor NRLC3 is a negative regulator of innate immune response. In this review we will discuss finding related with NLRC3 and its mechanism by which it alter cancer pathogenesis. Recently, it has been found that mice deficient in Nlrc3 are hyper-susceptible to colitis and colitis-associated colon carcinogenesis. Oncogenic inhibitory effect of NLRC3 is more dominant in epithelial compartment than hematopoietic compartment. It down regulates mTOR signaling and reduce cell proliferation. NLRC3 interact with PI3Ks and suppress activation of PI3K dependent kinase AKT. Understanding the role of NLRC3 in cancer may facilitate the recognition of new therapeutic strategies.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Fosfotransferasas
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Colitis
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Colon
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Neoplasias del Colon
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Citosol
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Proliferación Celular
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Inflamasomas
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Carcinogénesis
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Mano
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Inmunidad Innata
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Journal of Bacteriology and Virology
Año:
2018
Tipo del documento:
Article