Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
Genomics & Informatics
; : 71-74, 2018.
Article
en En
| WPRIM
| ID: wpr-716820
Biblioteca responsable:
WPRO
ABSTRACT
Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Pronóstico
/
Próstata
/
Neoplasias de la Próstata
/
Genoma
/
Conjunto de Datos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Genomics & Informatics
Año:
2018
Tipo del documento:
Article