The association between genetic polymorphisms of DNA repair genes XPD, XPC and susceptibility to laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 1199-1205, 2013.
Article
en Zh
| WPRIM
| ID: wpr-747151
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To analyze the association between genetic polymorphisms of DNA repair genes of XPD (751 Lys/Gln), XPC (PAT)and susceptibility to laryngeal carcinoma. To explore the effect between DNA repair genes of XPD (751 Lys/Gln), XPC (PAT) and carcinogenesis of LSCC(laryngeal squamous cell carcinoma).@*METHOD@#A case-control study was conducted involving 233 LSCC patients and 102 healthy controls to investigate the association between polymorphisms of XPD(751 Lys/Gln), XPC (PAT) and LSCC. All blood samples of the Han people from the Guang Dong Zone was analysze with methods of PCR, PCR-RFLP, ASA and the technique of checking DNA sequencing with sequenator. We explored the association between polymorphisms and the clinical pathologic characteristic of LSCC. The data was compute with SPSS13.0. Odds Ratios (ORs) with 95% CI for relevancy intensity were calculated using binary logistic regression analysis. REULT There is no difference of the frequency of XPC-PAT and XPD (751 Lys/Gln) genotype between in LSCC and in healthy contradistinguish (P > 0.05).@*CONCLUSION@#There may be no association between the susceptibility to laryngeal carcinoma and the genotype of XPC-PAT and XPD (751 Lys/Gln).
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Polimorfismo Genético
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Carcinoma de Células Escamosas
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Estudios de Casos y Controles
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Neoplasias Laríngeas
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Análisis de Secuencia de ADN
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Proteínas de Unión al ADN
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Reparación del ADN
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Proteína de la Xerodermia Pigmentosa del Grupo D
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Genética
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Genotipo
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2013
Tipo del documento:
Article