Study on the optimal concentration of Tanreqing injection based on the mathematical model of "net benefit-concentration median" / 国际中医中药杂志

ABSTRACT

Objective To explore the optimal concentration of Tanreqing injection for acute upper respiratory tract infections. Methods A retrospective analysis of 531 children with acute upper respiratory tract infection treated with Tanreqing injection was conducted. These children were divided into different groups according to concentration of Tanreqing injection (i.e., the relationship between liquid and solvent, or the dilution ratio of solvent to liquid). Assume that X was the dilution ratio of solvent to liquid and the group was divided by an additional increment of 2.5 dilution units. All the children were divided into six groups as follows, groups of A (1:10≤X<1:12.5), B (1:12.5≤X<1:15), C (1:15≤X<1:17.5), D (1:17.5≤X<1:20), E (1:20≤X<1:22.5) and F (1:22.5≤X<1:25). The clinical effective rate and incidence of adverse reactions in each group were used as clinical indicators related to concentration of Tanreqing injection. Origin 8 was used to establish the relationship between the two indicators and the median of the concentration, and to seek a net benefit index that can combine the two indicators together. Finally, the relationship between the net benefit indicator and the median of the concentration were established, and the optimal concentration was found by judging and picking up the maximum of the net benefit indicator. Results The relationship between the clinical effective rate and the concentration median were: Y=-0.3+31.58X-203.33X2 (R2=0.988 46), and relationship between the incidence of adverse reactions and the concentration median were: Y=-0.27+10.24X-67.85X2 (R2=0.982 28), and relationship between the net benefit indicator and the concentration median were: ΔY=-0.03+21.34X-135.48X2. The peak value of the net benefit indicator was 0.81, and the corresponding median of the concentration was 0.078 8, and the optimal dilution ratio of liquid to solvent was 1:11.6-1:14.1. Conclusions This article explored the optimum concentration range of Tanreqing injection and gave tips for clinical safety and effective drug use.