Xylaroisopimaranin A, a New Isopimarane Derivative from an Endophytic Fungus Xylaralyce sp
Natural Product Sciences
; : 228-232, 2019.
Article
en En
| WPRIM
| ID: wpr-760568
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WPRO
ABSTRACT
Five secondary metabolites, including a new isopimarane derivative xylaroisopimaranin A (1), were isolated from the endophytic fungus Xylaralyce sp. (HM-1), and their structures were elucidated by 1D, 2D NMR, MS and CD spectra. Their bioactivities were performed to antibacterial, Hep G2 cells cytotoxicity and brine shrimp inhibition. The biological evaluation results showed that the xylaroisopimaranin A (1), xylabisboein B (2), griseofulvin (3) , 5-methylmellein (4) and mellein-5-carboxlic acid (5) displayed no significant Hep G2 cells cytotoxicity and antibacterial acitivity, but they inhibited the brine shrimp with IC₅₀ from 0.5 to 25 µmol/mL.
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Índice:
WPRIM
Asunto principal:
Artemia
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Células Hep G2
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Hongos
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Griseofulvina
Idioma:
En
Revista:
Natural Product Sciences
Año:
2019
Tipo del documento:
Article