Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway
Experimental & Molecular Medicine
; : 92-97, 2008.
Article
en En
| WPRIM
| ID: wpr-77110
Biblioteca responsable:
WPRO
ABSTRACT
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron chi neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCalpha translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCalpha-ERK1/2 pathway.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Fosfoproteínas
/
Pirrolidinonas
/
Immunoblotting
/
Línea Celular
/
Supervivencia Celular
/
Calcio
/
Apoptosis
/
Fármacos Neuroprotectores
/
Endotelina-1
/
Endotelina-2
Límite:
Animals
Idioma:
En
Revista:
Experimental & Molecular Medicine
Año:
2008
Tipo del documento:
Article