Effects of CHL1 deficiency,a cell adhesion molecule,on the inflammatory bowel disease / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 4-7, 2018.
Article
en Zh
| WPRIM
| ID: wpr-773813
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effects of deficiency of CHL1 in inflammatory bowel disease (IBD).@*METHODS@#Dextran Sulfate Sodium (DSS)-induced colitis model was used to study the effects of deficiency of CHL1 on the development of IBD. Ten CHL1(+/+) mice in C57/BL6 background were randomly divided into CHL1(+/+) group and DSS-induced CHL1(+/+) group. Ten CHL1(-/-) mice in C57/BL6 background were randomly divided into CHL1(-/-) group and DSS-induced CHL1(-/-) group. DSS-induced CHL1(+/+) group and DSS-induced CHL1(-/-)group were fed with 1.5% DSS for 7 days, and then drinking distilled water for 2 days. CHL1(+/+) group and CHL1(-/-) group as control group were fed with distilled water for 9 days. The changes of weight, survival, fecal blood and the change of colon length in this study were observed.@*RESULTS@#On the 7 day, the weight of DSS-induced CHL1(-/-) group were reduced significantly, and DSS-induced CHL1(-/-) group had extreme mortality on the 9th day. The fecal blood of DSS-induced CHL1(-/-) group also had higher score than that of DSS-induced CHL1(+/+) group. In the DSS-induced CHL1(-/-) group,the length of colon was shortened obviously.@*CONCLUSIONS@#The loss of CHL1 aggravates the development of IBD.
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Índice:
WPRIM
Asunto principal:
Patología
/
Distribución Aleatoria
/
Moléculas de Adhesión Celular
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Sulfato de Dextran
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Colitis
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Colon
/
Modelos Animales de Enfermedad
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Genética
/
Ratones Endogámicos C57BL
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Año:
2018
Tipo del documento:
Article