Six new monacolin analogs from red yeast rice / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 394-400, 2019.
Article
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| WPRIM
| ID: wpr-776871
Biblioteca responsable:
WPRO
ABSTRACT
Six novel monacolin analogs, monacolins V-V (1-6), together with seven known ones (7-13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR (H-HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Monacolins V (2) and V (3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.
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WPRIM
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Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2019
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Article