Synthesis and biological activity of substituted xanthines as DPP-IV inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 947-2016.
Article
en Zh
| WPRIM
| ID: wpr-779261
Biblioteca responsable:
WPRO
ABSTRACT
In order to find more potential DPP-IV inhibitor, a series of xanthine-scaffold analogs of linagliptin, an approved antidiabetes drug, were designed and synthesized for SAR study. All compounds with a concentration of 50 nmol·L-1 showed the inhibitory activity against DPP-IV enzyme in vitro, and the inhibition rate of compounds 1a, 1d and 1f was over 50%. Virtual docking was also performed to facilitate the SAR analysis of these substituted xanthines.
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WPRIM
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2016
Tipo del documento:
Article