Analysis on 2621 cases of adverse drug reaction reports by Fishbone and Pareto di ag ram / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 88-92, 2018.
Article
en Zh
| WPRIM
| ID: wpr-790841
Biblioteca responsable:
WPRO
ABSTRACT
Objective To analyze the regularity and characteristics of 2621 cases of adverse drug reaction (ADR) occur-ring in our hospital during 2013-2016 ,and to explore the factors and causes of ADRs ,so as to provide evidence for the contin-uous improvement of rational use of drugs .Methods 2621 cases of ADR reports were retrospectively analyzed by monitoring software to extract ADR report source ,patient age and sex ,related pharmaceutical dosage forms ,routes of administration , clinical characterization ,organ involvement and other information .The Pareto method was used to identify the main drugs that caused ADR and ADR factorial analysis was performed with Fishbone diagram .Results ADR mainly reported by physicians (2573 cases ,98 .17% ) and pharmacists reported at least (3 cases ,0 .11% );population aged >70 years accounted for the lar-gest proportion (570 cases ,21 .74% );ADR mainly caused by intravenous infusion (1680 cases ,64 .10% ) .The clinical mani-festations were gastrointestinal system lesions (717 cases ,24 .17% ) .Pareto analysis showed that the main drug factors in-volved anti-infective drugs ,anti-neoplastic drugs ,Chinese medicine injections and parenteral nutrition drugs .Fishbone analysis showed that elderly patients ,intravenous administration ,incomplete monitoring and related drugs were the determining factors associated with ARDs .Conclusion The close attention should be paid to monitoring and guidance of special populations ,espe-cially the elderly ;reducing intravenous forms ,monitoring the main factors of medicines ,carrying out the individualized medica-tion monitoring ,strengthening clinical pharmacy ,in order to promote clinical rational use drug and reduce the occurrence of drug-induced diseases .
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1
Índice:
WPRIM
Tipo de estudio:
Guideline
/
Prognostic_studies
Idioma:
Zh
Revista:
Journal of Pharmaceutical Practice
Año:
2018
Tipo del documento:
Article