The Role of Notch Signaling in Bone Remodeling / 医用生物力学

ABSTRACT

Notch signaling pathway has a wide range of effects in the field of embryonic development, nervous system, vascular system, endocrine system and tumor. In recent years, studies have shown that Notch plays an important role in the regulation of bone metabolism, especially in bone remodeling. The disorder of bone remodeling is closely related to the progress of diseases such as osteoporosis and osteoarthritis. Notch signaling pathway can affect the process of bone remodeling by regulating the function of different cells in bone tissues, but its specific participation in different cells is still unknown. This review summarizes recent advances about the role of Notch signaling in bone remodeling.