Two new limonoids isolated from the fuits of Melia toosendan / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 692-696, 2016.
Article
en En
| WPRIM
| ID: wpr-812576
Biblioteca responsable:
WPRO
ABSTRACT
In the present study, two new limonoids, 1α, 7α-dihydroxyl-3α-acetoxyl-12α-ethoxylnimbolinin (1) and 1α-tigloyloxy-3α-acetoxyl-7α-hydroxyl-12β-ethoxylnimbolinin (2), together with other four known limonoids (3-6), were isolated from the fruits of Melia toosendan. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and ESI-MS) and comparisons with the data reported in the literature. The isolated compounds were evaluated for their antibacterial activities. Compound 4 exhibited significant antibacterial activity against an oral pathogen, Porphyromonas gingivalis ATCC 33277, with an MIC value of 15.2 μg·mL(-1). Compound 2 was also active against P. gingivalis ATCC 33277, with an MIC value of 31.25 μg·mL(-1). In conlcusion, our resutls indicate that these compounds may provide a basis for future development of novel antibiotics.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Farmacología
/
Medicamentos Herbarios Chinos
/
Espectroscopía de Resonancia Magnética
/
Estructura Molecular
/
Química
/
Porphyromonas gingivalis
/
Espectrometría de Masa por Ionización de Electrospray
/
Melia
/
Limoninas
/
Frutas
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2016
Tipo del documento:
Article