Reexamination of the diagnosis of fatty liver disease under the background of disease spectrum progression / 临床肝胆病杂志

ABSTRACT

Recent studies have shown that metabolic syndrome (MetS), e.g., obesity, diabetes mellitus, insulin resistance, and nonalcoholic fatty liver disease (NAFLD), and drinking coexist in a considerable number of individuals, suggesting the overlap of alcoholic liver disease (ALD) and NAFLD promotes the development and progression of fatty liver disease and aggravates the adverse outcome of fatty liver disease in a synergistic and interactive way. The evolution of the disease spectrum of fatty liver disease challenges the exclusive diagnosis system which divides fatty liver disease into ALD and NAFLD. This article summarizes the research advances in recent years and introduce the latest international consensus on the renaming of NAFLD, aiming to pay attention to the influence of drinking and MetS on NAFLD, put forward our insights into the diagnosis of fatty liver disease, and thus provide a new basis for reexamination the diagnosis and individualized treatment of fatty liver disease.