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Anti-LGI1 Limbic Encephalitis Presented with Atypical Manifestations
Experimental Neurobiology ; : 337-340, 2013.
Article en En | WPRIM | ID: wpr-84001
Biblioteca responsable: WPRO
ABSTRACT
Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1 LE that presented with atypical manifestations that complicated the diagnosis. A 62-year-old woman presented with a chronic course of memory disturbance and a subsequent relapse with an altered mental status after 10 months. The patient reported frequent chest pain of squeezing and dull nature, typically lasting 10-30 seconds. The chest pain was related to partial seizures, which were confirmed by video-EEG monitoring. Anti-LGI1 antibody was identified in serum and CSF. The patient's symptoms improved by immune modulation treatment. Patients with anti-LGI1 LE can experience atypical partial seizures, and a chronic relapsing course. Clinical suspicions and video-EEG monitoring are helpful for the early diagnosis and effective immune modulation.
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Texto completo: 1 Índice: WPRIM Asunto principal: Recurrencia / Convulsiones / Dolor en el Pecho / Encefalitis Límbica / Diagnóstico Precoz / Diagnóstico / Glioma / Memoria / Enfermedades del Sistema Nervioso Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: Experimental Neurobiology Año: 2013 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Recurrencia / Convulsiones / Dolor en el Pecho / Encefalitis Límbica / Diagnóstico Precoz / Diagnóstico / Glioma / Memoria / Enfermedades del Sistema Nervioso Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: Experimental Neurobiology Año: 2013 Tipo del documento: Article