Multi-drug resistance reversal agents from natural medicine and their advances / 国际药学研究杂志

ABSTRACT

Cancer has become the leading cause of death. Chemotherapy with comprehensive treatment is the main treatment for cancer patients. Multi-drug resistance (MDR)is one of the main obstacles limiting the efficacy of clinical chemotherapy treatment for tumors. Consequently, searching for highly effective and lowly toxic MDR reversal agents is an mportant work with regard to cancer drug development. Traditional Chinese medicines (TCM)and natural medicines, which have rich resouce, little drug side effects and varied chemical constituents are mportant sources for new MDR reversal agents. In this paper, the advances of MDR reversal agents from TCM and natural medicine since 2000 are reviewed.