Preparation of Inclusion Complex of Camptothecin with Cucurbit7uril and Exploration of the Properties of Inclusion Complex System / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1203-1208, 2018.
Article
en Zh
| WPRIM
| ID: wpr-858272
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WPRO
ABSTRACT
OBJECTIVE:
To prepare and verify the anticancer drug camptothecin(CPT) and its inclusion complex with cucurbit[7]uril(CB[7]).METHODS:
Camptothecin-cucurbit[7]uril inclusion complex was prepared by the lyophilization. The complex was characterized by fluorescence spectroscopy, Fourier transformation-infrared spectroscopy(FI-IR), differential scanning calorimetry(DSC), X-ray diffraction(XRD) and 1H-NMR. The dissolution properties of the inclusion complex was analyzed by ultraviolet spectrum.RESULTS:
The formation of 12 complex with CB[7] in aqueous solution was confirmed by fluorescence spectroscopy and the apparent stability constant was 3.95×1012 L2•mol-2.The stability and solubility of camptothecin was significantly improved after it was included with cucurbit[7]uril.CONCLUSION:
Stable complex can be formed between camptothecin and cucurbit[7]uril,and the solubility of camptothecin is increased by CB[7] significantly.
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WPRIM
Idioma:
Zh
Revista:
Chinese Pharmaceutical Journal
Año:
2018
Tipo del documento:
Article