Preparation of Inclusion Complex of Camptothecin with Cucurbit7uril and Exploration of the Properties of Inclusion Complex System / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare and verify the anticancer drug camptothecin(CPT) and its inclusion complex with cucurbit[7]uril(CB[7]). METHODS: Camptothecin-cucurbit[7]uril inclusion complex was prepared by the lyophilization. The complex was characterized by fluorescence spectroscopy, Fourier transformation-infrared spectroscopy(FI-IR), differential scanning calorimetry(DSC), X-ray diffraction(XRD) and 1H-NMR. The dissolution properties of the inclusion complex was analyzed by ultraviolet spectrum. RESULTS: The formation of 12 complex with CB[7] in aqueous solution was confirmed by fluorescence spectroscopy and the apparent stability constant was 3.95×1012 L2•mol-2.The stability and solubility of camptothecin was significantly improved after it was included with cucurbit[7]uril. CONCLUSION: Stable complex can be formed between camptothecin and cucurbit[7]uril,and the solubility of camptothecin is increased by CB[7] significantly.