Advances of genetics of age-related macular degeneration / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
; (12): 715-720, 2020.
Article
en Zh
| WPRIM
| ID: wpr-865333
Biblioteca responsable:
WPRO
ABSTRACT
Age-related macular degeneration (AMD) is one of the leading causes of blindness for the elderly over 50, characterized by loss of central vision irreversibly.The mechanism of AMD is not clear.In recent years, researchers have screened a variety of AMD-related genes ( CFH, ARMS2, HTRA1, etc.) and single nucleotide polymorphisms (SNPs) through genome-wide association study (GWAS). By testing these specific loci in high-risk populations, we can predict the risk of AMD, the subtypes, how AMD would develop, and how patients would react to treatment.There are few breakthroughs in the pathogenesis of the disease.Gene therapy focuses on anti-vascular endothelial growth factor (VEGF), complement pathway inhibition and RNA interference, by expressing functional proteins through transfection of adeno-associated virus vectors, but the safety and efficacy remains to be further evaluated.
Texto completo:
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Índice:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Experimental Ophthalmology
Año:
2020
Tipo del documento:
Article