Bile acid detection by biosensors-a review / 生物工程学报
Chinese Journal of Biotechnology
; (12): 2779-2790, 2020.
Article
en Zh
| WPRIM
| ID: wpr-878529
Biblioteca responsable:
WPRO
ABSTRACT
Bile acids facilitate the absorption of lipids, and affect the development of various diseases by regulating intestinal flora structure and modulating immunity and metabolism. It is therefore important to quantitatively detect bile acids. Current analytical methods are still immature due to constituent complexity, structural heterogeneity and bioactive variability of bile acids. Detection of individual bile acids is of significance for pharmacological research, clinical diagnosis and disease prevention. Advances have been made in bile acid analysis from multiple sources including serum, bile, urine and feces, although several limitations still exist for bile acid quantification. Here we review research progress in conventional bile acid assays, including spectrophotometry, thin-layer chromatography, liquid/gas chromatography and liquid/gas chromatography-mass spectrometry. Moreover, we emphasize the development of bile acid biosensors that may have promising prospects.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Bilis
/
Ácidos y Sales Biliares
/
Técnicas Biosensibles
/
Cromatografía en Capa Delgada
/
Cromatografía de Gases y Espectrometría de Masas
Tipo de estudio:
Diagnostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Año:
2020
Tipo del documento:
Article