A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins
Acta Pharmaceutica Sinica B
; (6): 588-597, 2021.
Article
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| WPRIM
| ID: wpr-881156
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WPRO
ABSTRACT
Organic carbonates (OCs) are a class of compounds featured by a carbonyl flanked by two alkoxy/aryloxy groups. They exist in either linear or cyclic forms, of which the majority encountered in nature adopt a pentacyclic structure. However, the enzymatic basis for pentacyclic carbonate ring formation remains elusive. Here, we reported that a four-protein metabolon (AlmUII-UV) assembled by a small peptide protein (AlmUV) appends a reactive
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WPRIM
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En
Revista:
Acta Pharmaceutica Sinica B
Año:
2021
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Article