Clinical analysis of two pediatric precursor B-cell acute lymphoblastic leukemia with C-MYC rearrangement / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
; (24): 687-690, 2021.
Article
en Zh
| WPRIM
| ID: wpr-882898
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To explore the characteristics, diagnosis, and treatment of precursor B-cell acute lymphocytic leukemia with C- MYC rearrangement (preBLL) in children.Methods:
The clinical data in 2 cases of childhood preBLL in Department of Hematology, Children′s Hospital Affiliated to Capital Institute of Pediatrics in June and August 2019 were summarized and analyzed.Results:
Both cases were acute lymphoblastic leukemia with precursor B-cell immunophenotype.Hepatosplenomegaly and peripheral white blood cells were significantly increased, and the morphology of bone marrow was L3. C- MYC rearrangement was discovered by cytogenetic tests.Both children have received the treatment of the mature B-cell tumor protocol (FAB/LMB96), and early remission was developed in 1 case with TP53 gene mutation but relapsed thereafter and died finally.Another case had reached sustained complete remission after treatment.Conclusions:
Children with preBLL is rare, and routine C- MYC rearrangement should be performed in children with Precursor B-cell lymphoblastic leukemia whose morphology of bone marrow was L3.Its treatment needs to be further studied, and multi-center clinical trials need to be actively conducted to analyze and summarize large numbers of cases to identify effective protocol and improve the prognosis.
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Guideline
/
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Applied Clinical Pediatrics
Año:
2021
Tipo del documento:
Article