Bioactive neolignans and lignans from the roots of Paeonia lactiflora / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 210-214, 2022.
Article
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| WPRIM
| ID: wpr-929253
Biblioteca responsable:
WPRO
ABSTRACT
Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC50 value of 7.28 ± 0.94 μmol·-1.
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Índice:
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Asunto principal:
Estereoisomerismo
/
Cromatografía Líquida de Alta Presión
/
Lignanos
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Raíces de Plantas
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Paeonia
Límite:
Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2022
Tipo del documento:
Article