New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 221-228, 2022.
Article
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| WPRIM
| ID: wpr-929255
Biblioteca responsable:
WPRO
ABSTRACT
Four new prenylflavonoid glycosides, namely koreanoside H-K (1-4), together with eleven known ones (5-15) were isolated from the leaves of Epimedium koreanum Nakai. Their structures were elucidated by 1D NMR, 2D NMR, HR-ESI-MS, IR and UV. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives. It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties, which were two extremely rare sugar units from the genus Epimedium. The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line. Compounds 1, 2 and 4 showed significant anti-pulmonary fibrosis activities.
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WPRIM
Asunto principal:
Extractos Vegetales
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Cromatografía Líquida de Alta Presión
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Hojas de la Planta
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Epimedium
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Glicósidos
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2022
Tipo del documento:
Article