Correlation between mammographic density and breast cancer-related reproductive risk factors in healthy women / 肿瘤研究与临床

ABSTRACT

Objective:To investigate the correlation between mammographic density (MD) and breast cancer-related reproductive risk factors in healthy women.Methods:A retrospective analysis was performed on 2 027 women who participated in breast health examinations in Shanxi Provincial People's Hospital from July 2019 to June 2021, and the mammography classifications were Breast Imaging Reporting and Data System (BI-RADS) categories 1-2. Quantra software was used to assess volume of fibroglandular (VFG) and volumetric breast density (VBD) in premenopausal and postmenopausal women, and the volume of non-fibroglandular (N-VFG) was calculated. Multiple linear regression analysis was used to analyze the correlation between MD and breast cancer-related reproductive risk factors.Results:Among the 2 027 healthy women, 1 149 (56.7%) were premenopausal women, and 96.3% (1 107 women) were reproductive women; 878 (43.3%) were postmenopausal women, and 97.6% (857 women) were reproductive women. Among 1 149 healthy premenopausal women, compared with nulliparous women, women who had given birth had lower VBD ( P = 0.036); among women who had given birth, with the increase of the number of births, VBD showed a downward trend, and N-VFG showed a trend of decline. Compared with women who gave birth once, VBD decreased by 1.12% ( P < 0.001), N-VFG increased by 27.01 cm 3 ( P = 0.043) in women who had given birth twice, and VBD decreased by 2.02% ( P < 0.001), N-VFG increased by 90.10 cm 3 ( P < 0.001) in women who had given birth ≥3 times. Among 878 healthy postmenopausal women, compared with non-breastfeeding women, the VFG and VBD showed a downward trend with the prolongation of breastfeeding time. When the breastfeeding time was ≥24 months, VFG decreased by 17.25 cm 3 ( P = 0.004) and VBD decreased by 3.23% ( P < 0.001). Among women who had given birth, with the increase in the number of births, VFG and VBD showed a downward trend, and N-VFG showed an upward trend. Compared with women who had given birth once, the VFG of women who had given birth twice decreased by 11.88 cm 3 ( P = 0.001), VBD decreased by 2.49% ( P < 0.001), the VFG of women who had given birth ≥3 times decreased by 21.26 cm 3 ( P < 0.001), VBD decreased by 4.19% ( P < 0.001), and N-VFG increased by 52.88 cm 3 ( P = 0.019). With the increase of the first birth age, VFG and VBD of women showed an increasing trend. Compared with women with the first birth age of ≤ 24 years old, VFG of women with the first birth age of 25-29 years old increased by 8.47 cm 3 ( P = 0.010), VBD increased by 1.16% ( P = 0.013), and the VFG of women with the first birth age of ≥30 years old increased by 16.25 cm 3 ( P = 0.018). Conclusions:There is a correlation between MD and breast cancer-related reproductive risk factors in healthy women with different menstrual status.