Ethanol extract of Kalopanax septemlobus leaf inhibits HepG2 human hepatocellular carcinoma cell proliferation via inducing cell cycle arrest at G
Asian Pacific Journal of Tropical Medicine
; (12): 344-350, 2016.
Article
en Zh
| WPRIM
| ID: wpr-951433
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To investigate the effects of an ethanol extract of Kalopanax septemlobus (Thunb.) Koidz. leaf (EEKS) on cell proliferation in human hepatocellular carcinoma cells and its mechanisms of action.Methods:
Cells were treated with EEKS and subsequently analyzed for cell proliferation and flow cytometry analysis. Expressions of cell cycle regulators were determined by reverse transcriptase polymerase chain reaction analysis and Western blotting, and activation of cyclin-associated kinases studied using kinase assays.Results:
The EEKS suppressed cell proliferation in both HepG2 and Hep3B cells, but showed a more sensitive anti-proliferative activity in HepG2 cells. Flow cytometry analysis revealed an association between the growth inhibitory effect of EEKS and with G
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Índice:
WPRIM
Idioma:
Zh
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2016
Tipo del documento:
Article