Antibiotic prophylaxis with intravenous ceftriaxone and fluoroquinolone reduces infectious complications after transrectal ultrasound-guided prostatic biopsy
Korean Journal of Urology
; : 466-472, 2015.
Article
en En
| WPRIM
| ID: wpr-95905
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
To assess the rates of infectious complications before and after the change of prophylactic antibiotic regimens in prostate needle biopsy. MATERIALS ANDMETHODS:
The records of 5,577 patients who underwent prostate needle biopsy at Asan Medical Center between August 2005 and July 2012 were retrospectively reviewed. Group 1 (n=1,743) included patients treated between 2005 and 2009 with fluoroquinolone for 3 days, group 2 (n=2,723) included those treated between 2009 and 2012 with ceftriaxone once before the biopsy and fluoroquinolone before biopsy and continue therapy for 3 days, and group 3 (n=1,111) received the same treatment for more than 7 days after the biopsy. Univariable and multivariable logistic regression models addressed risk factors associated with infectious complication after prostate needle biopsy.RESULTS:
Infectious complication after prostate needle biopsy developed in 18 (group 1), seven (group 2), and two patients (group 3) (p=0.001). In group 1, seven patients with infectious complication had positive blood cultures and harbored fluoroquinolone-resistant Escherichia coli, four had ceftriaxone susceptible isolates, and three had extended spectrum beta-lactamase-positive E. coli. Two patients in group 1 required intensive care because of septic shock. In multivariable analysis, the patients with combination of fluoroquinolone and ceftriaxone had significantly lower infectious complication rate than the fluoroquinolon alone (p=0.003).CONCLUSIONS:
Antibiotic prophylaxis with ceftriaxone and fluoroquinolone before prostate needle biopsy decreased the risk of potentially serious infectious complications.Palabras clave
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Índice:
WPRIM
Asunto principal:
Neoplasias de la Próstata
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Biopsia con Aguja
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Ceftriaxona
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Infección Hospitalaria
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Incidencia
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Estudios Retrospectivos
/
Ultrasonografía Intervencional
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Profilaxis Antibiótica
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Fluoroquinolonas
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Farmacorresistencia Bacteriana
Tipo de estudio:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Korean Journal of Urology
Año:
2015
Tipo del documento:
Article