Role of N6-methyladenosine RNA methylation in central nervous system: a review / 生物工程学报
Chinese Journal of Biotechnology
; (12): 45-59, 2023.
Article
en Zh
| WPRIM
| ID: wpr-970358
Biblioteca responsable:
WPRO
ABSTRACT
There are a variety of post-transcriptional modifications in mRNA, which regulate the stability, splicing, translation, transport and other processes of mRNA, followed by affecting cell development, body immunity, learning and cognition and other important physiological functions. m6A modification is one of the most abundant post-transcriptional modifications widely existing in mRNA, regulating the metabolic activities of RNA and affecting gene expression. m6A modified homeostasis is critical for the development and maintenance of the nervous system. In recent years, m6A modification has been found in neurodegenerative diseases, mental diseases and brain tumors. This review summarizes the role of m6A methylation modification in the development, function and related diseases of the central nervous system in recent years, providing potential clinical therapeutic targets for neurological diseases.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
ARN
/
ARN Mensajero
/
Sistema Nervioso Central
/
Metilación
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Año:
2023
Tipo del documento:
Article