Factor analysis on serum biomarkers in patients with stage Ⅰ silicosis / 中国职业医学
China Occupational Medicine
; (6): 687-691, 2022.
Article
en Zh
| WPRIM
| ID: wpr-976102
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WPRO
ABSTRACT
@#Objective , To investigate the role of serum chemokines and oxidative and antioxidant biomarkers in occupational ( silicosis) Methods silicosis hereinafter referred to as . A total of 58 patients with stage Ⅰ silicosis were selected as the - ( ), research subjects using convenient sampling method. The serum levels of nuclear factor erythroid 2 related factor 2 Nrf2 -( - ) - ( - - ) - heme oxygenase 1 HO 1 and 8 isoprstaglandin F2α 8 iso PGF2α were determined by enzyme linked immunesorbent assay. ( ) ( - ) The serum levels of lipid peroxide LPO and total antioxidant capacity TAOC were determined by chemistry colorimetric method. - - ( - ), Luminex flow fluorescence technology was used to detect the serum levels of interferon γ inducible protein10 IP10 macrophage ( )- , - - ( ) inflammatory protein MIP 1α MIP1β and macrophagederived chemokine MDC . The above indicators were analyzed by factor Results - analysis. The information extraction rate of the original indicators of the nine biomarkers was 58.5%96.5%. Four common , , ( ) , factors were extracted including Nrf2 antioxidant signaling pathway helper T cell Th 1 dominant chemotaxis the total , , , , , oxidation/antioxidant balance and Th2 dominant chemotaxis whose variance contribution rates were 32.2% 19.1% 16.4% , , Conclusion - and 11.8% respectively and the cumulative variance contribution rate was 79.5%. Both the oxidant antioxidant , disturbance and the dominance chemotaxis are involved in the occurrence and development of silicosis and the Nrf2 antioxidant signaling pathway plays the most critical role.
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WPRIM
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Zh
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China Occupational Medicine
Año:
2022
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Article