Calculation of likelihood ratio for X-STR typing in kinship testing / 法医学杂志
Journal of Forensic Medicine
; (6): 180-184, 2013.
Article
en Zh
| WPRIM
| ID: wpr-983816
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To deduce the calculation formulae of likelihood ratio for kinship testing with X-short tandem repeat (X-STR) typing.@*METHODS@#With the identity by decent coefficient of different relationships, the joint genotypic probability of two individuals with specific genotypes was calculated as X value, and then the joint genotypic probability of two unrelated individuals was calculated as Y value; therefore, the likelihood ratio value (X/Y) was obtained.@*RESULTS@#The calculation formulae of the likelihood ratio for different genotype combinations of the female-female, female-male and male-male genetic relationships were derived and verified by real cases.@*CONCLUSION@#The calculation formulae are simple and accurate to evaluate the likelihood ratio for two individuals' genetic relationship with X-STR typing. The formulae provide the basic potential value for the difficult kinship testing with X-STR loci.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Algoritmos
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Funciones de Verosimilitud
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Reacción en Cadena de la Polimerasa
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Repeticiones de Microsatélite
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Cromosomas Humanos X
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Alelos
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Genética Forense
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Frecuencia de los Genes
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Genotipo
Límite:
Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Año:
2013
Tipo del documento:
Article