Nasal polyposis: more than a chronic inflammatory disorder-a disease of mechanical dysfunction - the São paulo position
Int. arch. otorhinolaryngol. (Impr.)
; 23(2): 241-249, 2019. ilus, tab
Article
Dans En
| LILACS
| ID: biblio-1015650
Responsable en Bibliothèque :
BR66.1
ABSTRACT
Introduction:
The importance of our study lies in the fact that we have demonstrated the occurrence ofmechanical dysfunction within polypoid tissues, which promotes the development of polyps in the nasal cavity.Objective:
To change the paradigm of nasal polyposis (NP). In this new conception, the chronic nasal inflammatory process that occurs in response to allergies, to pollution, to changes in the epithelial barrier, or to other factors is merely the trigger of the development of the disease in individuals with a genetic predisposition to an abnormal tissue remodeling process, which leads to a derangement of the mechanical properties of the nasal mucosa and, consequently, allows it to grow unchecked. Data Synthesis We propose a fundamentally new approach to intervening in the pathological process of NP, addressing biomechanical properties, fluid dynamics, and the concept of surface tension.Conclusion:
The incorporation of biomechanical knowledge into our understanding of NP provides a new perspective to help elucidate the physiology and the pathology of nasal polyps, and new avenues for the treatment and cure of NP (AU)
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Polypes du nez
/
Inflammation
Limites du sujet:
Humans
Pays comme sujet:
America do sul
/
Brasil
langue:
En
Texte intégral:
Int. arch. otorhinolaryngol. (Impr.)
Thème du journal:
OTORRINOLARINGOLOGIA
Année:
2019
Type:
Article