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Semi-quantitative evaluation of brain gliomas in adults: A focus on neuropathological characteristics
Rodríguez-Florido, Marco Antonio; Feria-Romero, Iris A; Nettel-Rueda, Bárbara; Guerrero-Cantera, José; Orozco-Suárez, Sandra; Chavez, Jesús A; Guinto, Gerardo; Grijalva, Israel.
Affiliation
  • Rodríguez-Florido, Marco Antonio; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Unit of Medical Research in Neurological Diseases. Mexico City. MX
  • Feria-Romero, Iris A; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Unit of Medical Research in Neurological Diseases. Mexico City. MX
  • Nettel-Rueda, Bárbara; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Department of Neurosurgery. Mexico City. MX
  • Guerrero-Cantera, José; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Unit of Medical Research in Neurological Diseases. Mexico City. MX
  • Orozco-Suárez, Sandra; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Unit of Medical Research in Neurological Diseases. Mexico City. MX
  • Chavez, Jesús A; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Unit of Medical Research in Neurological Diseases. Mexico City. MX
  • Guinto, Gerardo; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Department of Neurosurgery. Mexico City. MX
  • Grijalva, Israel; Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI. Unit of Medical Research in Neurological Diseases. Mexico City. MX
Gac. méd. Méx ; Gac. méd. Méx;155(5): 439-446, Sep.-Oct. 2019. tab, graf
Article de En | LILACS | ID: biblio-1286540
Bibliothèque responsable: BR1.1
ABSTRACT

Introduction:

Gliomas are neoplasms with high recurrence and mortality. Due to the difficulty to apply the World Health Organization (2016) classification, developing countries continue to use histological evaluation to diagnose and classify these neoplasms.

Objective:

To develop a semi-quantitative scale to numerically grade gliomas by its morphological characteristics.

Method:

A cohort of patients with gliomas was assessed and followed for 36 months. Tumor tissue sections were analyzed and graded, including aspects such as cell line, cellularity, nuclear pleomorphism, mitosis, endothelial hyperplasia, hypoxic changes, apoptotic bodies, necrosis, hemorrhage and proliferation index.

Results:

58 cases were analyzed. Low-grade gliomas median score was 12 points (9 and 13.5 for percentiles 25 and 75, respectively), whereas for high-grade gliomas it was 17 points (16 and 20.5 for percentiles 25 and 75, respectively) (p < 0.0001). Thirty-six-month survival of patients with low (13/17) and high grade gliomas (6/41) was also significantly different (p < 0.0001).

Conclusions:

The semi-quantitative morphological scale allows an objective evaluation of gliomas, with an adequate correlation between the score, tumor grade and survival time.
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Tumeurs du cerveau / Gliome Type d'étude: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limites du sujet: Adult / Female / Humans / Male langue: En Texte intégral: Gac. méd. Méx Thème du journal: MEDICINA Année: 2019 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Tumeurs du cerveau / Gliome Type d'étude: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limites du sujet: Adult / Female / Humans / Male langue: En Texte intégral: Gac. méd. Méx Thème du journal: MEDICINA Année: 2019 Type: Article