Your browser doesn't support javascript.
loading
Do the Different Types of Pulmonary Hypertension Cause the Same Effect on Right Heart and Serum Asymmetrical Dimethylarginine Levels in Female Patients?
Taçoy, G; Başer, HD; Çengel, A; Başer, K; Kuş, Ö; Tuncel, AF; Bolayir, A; Paşaoğlu, H; Boyaci, B; Yalçin, R.
Affiliation
  • Taçoy, G; Gazi University. Faculty of Medicine. Cardiology Department. Besevler. TR
  • Başer, HD; Gazi University. Faculty of Medicine. Cardiology Department. Besevler. TR
  • Çengel, A; Gazi University. Faculty of Medicine. Cardiology Department. Besevler. TR
  • Başer, K; Turkiye Yuksek Ihtisas Hospital. Cardiology Department. TR
  • Kuş, Ö; Turkiye Yuksek Ihtisas Hospital. Cardiology Department. TR
  • Tuncel, AF; Gazi University. Faculty of Medicine. Biochemistry Department. Besevler. TR
  • Bolayir, A; Gazi University. Faculty of Medicine. Cardiology Department. Besevler. TR
  • Paşaoğlu, H; Gazi University. Faculty of Medicine. Biochemistry Department. Besevler. TR
  • Boyaci, B; Gazi University. Faculty of Medicine. Cardiology Department. Besevler. TR
  • Yalçin, R; Gazi University. Faculty of Medicine. Cardiology Department. Besevler. TR
West Indian med. j ; West Indian med. j;69(1): 26-31, 2021. tab
Article de En | LILACS | ID: biblio-1341861
Bibliothèque responsable: BR1.1
ABSTRACT
ABSTRACT

Objective:

Right-heart function is a major determinant of clinical outcome in patients with elevated pulmonary artery pressure due to pulmonary venous hypertension (PVH) and pulmonary arterial hypertension (PAH). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase. This study aimed to evaluate if different types of pulmonary hypertension (PH) would cause the same effect on right-heart functions and serum ADMA levels in female patients.

Methods:

This study included patients with PAH as group I, patients with PVH due to mitral stenosis (mitral valve area ≤ 1.5 cm2, without any additional valve or left-heart disease and systolic pulmonary artery pressure ≥ 50 mmHg in transthoracic echocardiography) as group II, and healthy control subjects as group III. Transthorasic echocardiographic evaluations for right-heart functions were performed according to the guidelines of the American Society of Echocardiography. Venous blood samples were collected, and the serum ADMA concentrations were obtained with the ELISA kit (DRG® International Inc., Springfield, NJ, USA).

Results:

Patients in groups I and II had higher ADMA levels than healthy control subjects. Right-atrium area and dimensions, right-ventricular (RV) volumes, grade of tricuspid regurgitation, systolic pulmonary arterial pressure, RV wall thickness, and RV outflow tract diameters were significantly higher in group I patients than in group II patients. Right-ventricular myocardial performance index was lower, and RV fractional area change and tricuspid valve systolic tissue Doppler velocity were higher in group II patients than in group I patients.

Conclusion:

This study demonstrated that both PAH and PVH caused increase in right-heart dimensions and impairment in right-heart functions.
Sujet(s)
Mots clés

Texte intégral: 1 Indice: LILACS Sujet Principal: Arginine / Nitric oxide synthase / Hypertension pulmonaire Type d'étude: Guideline Limites du sujet: Adolescent / Adult / Aged / Female / Humans langue: En Texte intégral: West Indian med. j Thème du journal: MEDICINA Année: 2021 Type: Article

Texte intégral: 1 Indice: LILACS Sujet Principal: Arginine / Nitric oxide synthase / Hypertension pulmonaire Type d'étude: Guideline Limites du sujet: Adolescent / Adult / Aged / Female / Humans langue: En Texte intégral: West Indian med. j Thème du journal: MEDICINA Année: 2021 Type: Article