Evaluation of interactions of silibinin with the proteins ALS3 and SAP5 against Candida albicans / Avaliação das interações da silibinina com as proteínas ALS3 e SAP5 contra Candida albicans
J. Health Biol. Sci. (Online)
; 10(1): 1-6, 01/jan./2022. tab, ilus
Article
de En
| LILACS
| ID: biblio-1370924
Bibliothèque responsable:
BR1780.2
ABSTRACT
Objective:
to evaluate the molecular interaction of silibinin with the targets ALS3 and SAP5.Methodology:
Molecular docking protocols were conducted to analyze the binding interaction of silibinin with ALS3 and SAP5.Results:
Eleven interactions of ALS3 with silibinin and four with fluconazole were found, while six interactions were observed of SAP5 with silibinin and four with fluconazole.Conclusion:
Molecular docking between silibinin and ALS3 identified important interactions, but no significant interactions were observed with SAP5, even though silibinin can exhibit affinity and interactions with other SAP5 sites.RESUMO
Objetivo:
Avaliar a interação molecular da silibinina com os alvos ALS3 e SAP5.Metodologia:
Protocolos de docking molecular foram conduzidos para analisar a interação de ligação da silibinina com ALS3 e SAP5.Resultados:
Foram encontradas onze interações de ALS3 com silibinina e quatro com fluconazol, enquanto seis interações foram observadas de SAP5 com silibinina e quatro com fluconazol.Conclusão:
Docking molecular entre silibinina e ALS3 identificou interações importantes, mas não foram observadas interações significativas com SAP5, embora a silibinina possa apresentar afinidade e interações com outros sítios SAP5.Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Silymarine
/
Candida albicans
langue:
En
Texte intégral:
J. Health Biol. Sci. (Online)
Thème du journal:
Cincias da Sa£de
/
Disciplinas das Cincias Biol¢gicas
Année:
2022
Type:
Article