Predictive factors of melanoma thickness
An. bras. dermatol
; 97(5): 601-605, Sept.-Oct. 2022. tab
Article
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LILACS-Express
| LILACS
| ID: biblio-1403155
Bibliothèque responsable:
BR1.1
ABSTRACT
Abstract Background:
Melanoma thickness is a relevant prognostic marker that is crucial for staging and its calculation relies on the histopathological examination. There is a risk of thickness underestimation with an incisional biopsy if the latter is not performed on a tumor area where the thickness is maximal. This occurrence may have an impact on a therapeutic decision, particularly regarding the excision margins and the need for sentinel lymph node biopsy.Objective:
To assess the association between melanoma thickness and dermoscopic, demographic, epidemiological and clinical variables, aiming to identify predictive factors of thickness >1 mm.Methods:
This was an observational and cross-sectional study, carried out on patients diagnosed with melanoma, from a single center over a time span of four years. Anatomopathological (thickness), dermoscopic, demographic, epidemiological, and clinical variables were collected. The associations between the variables with melanoma thickness were assessed.Results:
A total of 119 patients were included. The presence of atypical vessels on the dermoscopic examination was an independent predictive factor of thickness >1 mm. Conversely, an atypical reticular pattern predicted melanoma thickness <1 mm. The presence of ephelides and a previous history of sunburn were also associated with melanomas thinner than 1 mm in the univariate analysis. Studylimitations:
The lack of data related to some variables and the absence of an optimal correlation between the dermoscopic and the anatomopathological examination constituted study limitations.Conclusion:
An atypical vascular pattern on dermoscopy is associated with thickness >1 mm, helping with the choice of the optimal site to perform an incisional biopsy when an excisional biopsy is not feasible.
Texte intégral:
1
Indice:
LILACS
Type d'étude:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
langue:
En
Texte intégral:
An. bras. dermatol
Thème du journal:
DERMATOLOGIA
Année:
2022
Type:
Article