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Efficacy and safety of chloroquine and hydroxychloroquine for the treatment of COVID19 infection: An umbrella review
Digamo, Kidist; Demissie, Mekdes; Amogne, Wondwossen; Tolossa, Dejene; Fekadu, Wubalem.
Affiliation
  • Digamo, Kidist; Addis Ababa University, Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT- Africa), Addis Ababa, Ethiopia. Wachemo University, College of Medicine and Health Sciences, Department of Pharmacy, Hossana, Ethiopia. Addis Ababa. ET
  • Demissie, Mekdes; Addis Ababa University, Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT- Africa), Addis Ababa, Ethiopia. Haramaya University, College of Health and Medical Sciences, School of nursing and midwifery, Haramaya, Ethiopia. Haramaya University, College of Health and Medical Sciences, School of nursing and midwifery, Haramaya, Ethiopia. Addis Ababa. ET
  • Amogne, Wondwossen; Addis Ababa University, College of Health Sciences, Department of Internal Medicine, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Tolossa, Dejene; Addis Ababa University, Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT- Africa), Addis Ababa, Ethiopia. Firoomsis Hospital, Jimma, Ethiopia. Addis Ababa. ET
  • Fekadu, Wubalem; Addis Ababa University, Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT- Africa), Addis Ababa, Ethiopia. Addis Ababa University, WHO collaborating center for Mental Health research and capacity building, Department of Psychiatry, College of Health sciences, Addis Ababa, Ethiopia. Brighton and Sussex Medical School, Global Health and Infection Department, Brighton, UK. Addis Ababa. ET
Ethiop. med. j. (Online) ; 60(Supplement 1): 76-86, 2022. figures, tables
Article de En | AIM | ID: biblio-1433728
Bibliothèque responsable: CG1.1
ABSTRACT

Introduction:

Among all therapeutic approaches for COVID-19, most controversies have been raised about the efficacy and safety hydroxychloroquine (HCQ) and chloroquine. We conducted an umbrella review to assess any potential benefits of hydroxychloroquine and chloroquine in treating COVID-19.

Methods:

We searched the Cochrane Database of Systematic Reviews, PubMed and covid-evidence.org from December 2019 until July 2022. Time to viral clearance, need for mechanical ventilation and mortality were assessed as main efficacy outcomes. The analysis was performed using R package version 4.1.2.

Result:

Hydroxychloroquine had no benefit in decreasing time to viral clearance at days 7 (RR 0.81; 95% CI 0.63, 1.03) and 14 (RR 1.00; 95% CI 0.90, 1.139). Chloroquine has no statistically significant effect in decreasing the time of viral negativity at days 7 (RR 1.20; 95%CI 0.64, 2.25) and 14 (RR 1.08; 95%CI 0.85, 1.36). There is no difference in the need for mechanical ventilation among hydroxychloroquine plus azithromycin versus standard of care groups. Hydroxychloroquine marginally increased the mortality rate compared to placebo but not statistically significant (RR 1.09; P-value 0.05). Adding azithromycin to hydroxychloroquine had no statistically significant effect of decreasing mortality (RR 0.52; 95%CI 0.13, 2.07). Treatments with hydroxychloroquine increased the risk of adverse effects (RR 2.71; 95%CI 1.66, 4.43; p-value <0.0001). Adding azithromycin to hydroxychloroquine increased the adverse events (RR 1.74; 95% CI 1.27, 2.38).

Conclusion:

Though access to antivirals is an important challenge in developing countries, the decision to sus-pend hydroxychloroquine and chloroquine in treating COVID-19 appears right
Sujet(s)
Mots clés
Texte intégral: 1 Indice: AIM Sujet Principal: Thérapeutique / Chloroquine / COVID-19 / Hydroxychloroquine Type d'étude: Clinical_trials / Systematic_reviews Limites du sujet: Female / Humans / Male langue: En Texte intégral: Ethiop. med. j. (Online) Année: 2022 Type: Article
Texte intégral: 1 Indice: AIM Sujet Principal: Thérapeutique / Chloroquine / COVID-19 / Hydroxychloroquine Type d'étude: Clinical_trials / Systematic_reviews Limites du sujet: Female / Humans / Male langue: En Texte intégral: Ethiop. med. j. (Online) Année: 2022 Type: Article