Comparative Assessment of E-cadherin's Expression between the Metastatic and Non-metastatic Oral Squamous Cell Carcinoma: An Immunohistochemical Study
Pesqui. bras. odontopediatria clín. integr
; 23: e220077, 2023. tab, graf
Article
de En
| LILACS, BBO
| ID: biblio-1529117
Bibliothèque responsable:
BR1264.1
ABSTRACT
ABSTRACT Objective:
To identify the clinicopathological correlation of E-cadherin expression in metastatic and non-metastatic oral squamous cell carcinoma (OSCC). Material andMethods:
A total of 90 paraffin-embedded tissue sections of OSCC were retrieved from the registry. The total selected samples were 45 cases each from the primary lesions of metastatic and non-metastatic OSCC. One section was subjected to routine Hematoxylin and eosin stain and another to immunohistochemical analysis for E-cadherin expression.Results:
A non-significant (p˃0.05) increased expression is seen in the non-metastatic group compared to the metastatic group, with predominantly membrane as the staining site in either group. However, the expression of E-cadherin did not reveal any statistically significant association with independent variables such as age, gender, and adverse habits of the patients (p>0.05). On the other hand, with respect to the histological differentiation of OSCC, a significant association (p<0.001) was observed with the well-differentiated type of metastatic OSCC.Conclusion:
E-cadherin was useful to some extent in predicting regional metastasis. However, further studies using a panel of biomarkers with increased sample size may help us understand the process involved in metastasis.Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Marqueurs biologiques
/
Cadhérines
/
Adhérence cellulaire
/
Carcinome épidermoïde de la tête et du cou
Type d'étude:
Evaluation_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
langue:
En
Texte intégral:
Pesqui. bras. odontopediatria clín. integr
Thème du journal:
ODONTOLOGIA
Année:
2023
Type:
Article