Intravital Microscopy Evidence That Methylene Blue Should Be a Vasopressor-Sparing Agent in Sepsis Vasoplegia

Mestriner, Fabiola Leslie Antunes Cardoso; Dantas, Pedro Brüch; Barbosa, Jéssyca Michelon; Evora, Paulo Roberto B.; Becari, Christiane

Mestriner, Fabiola Leslie Antunes Cardoso; Dantas, Pedro Brüch; Barbosa, Jéssyca Michelon; Evora, Paulo Roberto B.; Becari, Christiane.

Mestriner, Fabiola Leslie Antunes Cardoso; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Department of Surgery and Anatomy. Ribeirão Preto. BR
Dantas, Pedro Brüch; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Department of Surgery and Anatomy. Ribeirão Preto. BR
Barbosa, Jéssyca Michelon; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Department of Surgery and Anatomy. Ribeirão Preto. BR
Evora, Paulo Roberto B.; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Department of Surgery and Anatomy. Ribeirão Preto. BR
Becari, Christiane; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Department of Surgery and Anatomy. Ribeirão Preto. BR

Rev. bras. cir. cardiovasc ; 39(3): e20230066, 2024. tab, graf

Article Dans En | LILACS-Express | LILACS | ID: biblio-1559395

Responsable en Bibliothèque : BR1.1

ABSTRACT

ABSTRACT

ABSTRACT Microvasculature failure is expected in sepsis and at higher amine concentrations. Therefore, special attention focused individually on microcirculation is needed. Here, we present that methylene blue can prevent leukocytes from adhering to the endothelium in a rat model of lipopolysaccharide-induced endotoxemia. As hypothesis evidence, an intravital microscopy image is presented.

Endothelium; Lipopolysaccharides; Methylene Blue; Microcirculation; Microvessels

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Texte intégral: 1 Indice: LILACS langue: En Texte intégral: Rev. bras. cir. cardiovasc Thème du journal: CARDIOLOGIA / CIRURGIA GERAL Année: 2024 Type: Article / Project document

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